Introduction to Radiopharmacy
Edition 11/12 of the Webinar Series on Basic Nuclear Medicine
Created in cooperation with IAEA

Brief summary of contents

The concept, manufacturing, quality control and use of diagnostic radiopharmaceuticals is presented. Then more detailed and in-depth information about SPECT, Ga68, FDG and GMP is provided. The presentation ends with a brief summary of the five chapters.

Content: Presentation and MCQ test (19 questions)
Length: 00:56:27

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Small Animal Imaging
Edition 10/12 of the Webinar Series on Basic Nuclear Medicine
Created in cooperation with IAEA

Brief summary of contents

This webinar describes some of the practical considerations that need to be taken into account when performing PET or SPECT imaging on small animals such as mice or rats.

Content: Presentation and MCQ test (10 questions)
Length: 00:46:36 min

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Basic PET physics and instrumentation - Part 2
Edition 9/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

This presentation illustrates how data are acquired in PET and the principles of time coincidence measurements. It also describes the describes the sources of noise in PET image with the analysis of the meaning of true, scatter and random coincidences and of the noise equivalent count rate. The concept of Time-of-Flight PET concept is illustrated together with a description of the CT based attenuation correction of PET data. An brief overview of present PET/CT systems is also shown.

Content: Presentation and MCQ test (10 questions)
Length: 00:45:11 min



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Basic PET physics and instrumentation - Part 1
Edition 8/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

This presentation illustrates the physics behind PET from basic to more advanced topics, starting from the description of positron emission and annihilation processes. A particular effort is devoted to the analysis of factors limiting spatial resolution of PET including physics-related factors and technological factors. An introduction on the present technology for the construction of a PET detector is also included with a description of the scintillator materials and photodetector technologies.

Content: Presentation and MCQ test (10 questions)
Length: 00:45:11 min



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(Radio)Tracer Development
Edition 7/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

- How of ‘PETable’ molecular targets are identified
- Understanding the physicochemical and pharmacological properties that are used as selection criterion to give maximum likelihood of a new molecule producing a useable PET imaging agent (affinity, specificity, kinetic parameter etc.)
- The importance of choice of radionuclide
An appreciation of the instrumentation and automation used in the synthesis of PET radiotracers.
- Scaling up of radiotracer production (from low radioactivity proof-of-concept studies to full multi patient clinical application)
- Quality aspects and specifications for of PET radiotracers
- The importance of specific activity, metabolism and labelling position
- The evaluation of radiotracers using in vitro, ex vivo and in vivo approaches
- How a radiotracer becomes a radiopharmaceutical: dossiers, regulations, authorities

Content: Presentation and MCQ test (10 questions)
Length: 00:48:27 min



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Basic Principles of RNT and Common Clinical Applications
Edition 6/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

Radionuclide therapy is a growing field of interest within nuclear medicine. Originally, radioiodine was the cornerstone in the treatment of thyroid disorders, such as hyperthyroidism and thyroid cancer. Over the past decennia, many other treatment options have become available, such I131-MIBG, Lu177-DOtatate, Ytrrium-90, etc., for benign as well as malignant entities. Therefore, it is essential for the practicing nuclear medicine physician to have a good understanding of the basic aspects of RNT.

This webinar provides an overview of the radiobiological aspects of RNT, the effects and side effect of treatment. Self-irradiation, crossfire and Bystander effects are clarified in relation to alpha, beta and gamma radiation. Moreover, several stochastic and deterministic effects of RNT will be presented. In addition, therapy evaluation and outcome, such as overall and disease free survival, are discussed and related to several clinical entities. Additive and synergistic therapeutic options are addressed in relation to combined RNT. Finally, general contraindications, common precautions and regulations related to RNT are reviewed. 

Content: Presentation and MCQ test (15 questions)
Length: 00:56:20 min



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Introduction to Inflammation and Infection Imaging
Edition 5/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

This is an introductory webinar, introducing the viewer to imaging infections and inflammation with nuclear medicine techniques. While infection and inflammation are commonly encountered in the clinical scenario, the use of nuclear medicine techniques within the treatment algorithm can be further enhanced. This introduction covers the pathophysiology leading to the choice of radiopharmaceuticals available and the clinical scenarios where these can be effectively used.  

Content: Presentation and MCQ test (15 questions)
Length: 00:47:44 min



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Introduction to Nuclear Medicine in Neurology: bases for clinical use
Edition 4/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

- Overview of tracers for CNS imaging
- Neurodegenerative Dementia
- Parkinsonian Syndromes
- Epilepsy
- Brain Tumors

For every clinical scenario, pathophysiological and clinical background for NM Imaging, tracers distribution and diagnostic contribution as well as demonstrative cases with Q&A have been included. 

Content: Presentation and MCQ test (14 questions)
Length: 00:48:08 min



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Basic Radiopharmaceutical Dosimetry
Edition 3/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

After a short presentation of the clinical indications sorted as a function of the relevance of dosimetry, a step by step presentation of the MIRD formalism is presented:

  • Absorbed fraction and specific absorbed fraction
  •  Penetrating/non-penetrating radiations
  •  Absorbed dose rate according to the MIRD formalism
  •  Cumulated activity and residence time
  • Mird general equation and simplified equation 

Anthropomorphic models; evolution from mathematical to voxel-based and hybrid models.

Diagnostic dosimetry vs Therapy dosimetry: from model-based to patient specific dosimetry.

Examples of dosimetric software available in the literature 

Practical example/exercise.

Content: Presentation and MCQ test (9 questions)
Length: 00:32:11 min



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Stress Testing Protocols
Edition 2/12 of the Webinar Series on Basic Nuclear Medicine

Created in cooperation with IAEA

Brief summary of contents

Stress testing is essential in the diagnosis of CAD. For myocardial perfusion imaging several stressors with different profiles and side effects are available for routine practice. It is essential for the practicing nuclear medicine physician and the technologist to have a good understanding of their physiological mechanisms, their indications and their side effects in order to select the most appropriate individual stress test. This webinar provides an overview of the different stressors, the associated protocols, indications and contraindications as well as side effects.

Content: Presentation and MCQ test (5 questions)
Length: 00:21:47 min



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The (Patho)physiology of Bone turnover

Edition 1/12 of the Webinar Series on Basic Nuclear Medicine
Created in cooperation with IAEA

Brief summary of contents

The skeleton is one of the largest organs of the human body, and within nuclear medicine bone scintigraphy is an important part of routine practice. Therefore it is essential for the practicing nuclear medicine physician to have a good understanding of the physiological mechanisms within skeletal structures.

This webinar provides an overview of the cells, regulators, and processes occurring within bone enabling its major functions. In particular, bone formation, modeling and remodeling, and fracture healing are addressed. A number of bone diseases are frequently encountered in daily clinical nuclear medicine, including infection, inflammation, osteoporosis and malignancy. The pathophysiological mechanisms, including cell biology, and the role of the immune system and key local mediators in these diseases are reviewed.

Content: Presentation and MCQ test (8 questions)
Length: 00:41:29 min



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